Djufaston - hormonal drug, the selective progesterone analogue to the mucous membrane of the uterus (the endometrium). It inhibits proliferation (proliferation) of the endometrium in the first phase of the menstrual cycle and provides an offensive phase secretion. It normalizes the menstrual cycle. Duphaston is widely used in the first half of pregnancy as a source of progesterone.

How does djufaston

Duphaston (active substance - dydrogesterone) is a synthetic analogue of progesterone, that is progestin or progestin. It produces tablets of ten milligrams American (now international) pharmaceutical company Abbott. Duphaston mechanism of action is the same as that of the progesterone, but synthetic analogue advantage that he ingested, unlike natural progesterone, which could be administered only by injection of an oily solution.

However, he does not suppress the effects of estrogen (female sex hormones second half of pregnancy) and has no negative effect on the liver. It also does not exhibit the properties of male sex hormones (androgens), as it is not their derivatives. This is very important since the derivatives of androgens contribute in building body mass and increased thrombosis.

Djufaston not a contraceptive drug, and can not be used for this purpose as it does not inhibit ovulation (yield egg from the ovary). Therefore, in the treatment of menstrual cycle, a woman could become pregnant How to Get Pregnant: Recommendations to help .

Which diseases appoint djufaston

Duphaston is often prescribed in the early stages of pregnancy (the first and partially in the second trimester) for preventing pregnancy loss - it inhibits the contraction of muscles of the uterus, without causing any negative effects on the child.

Widely used djufaston Djufaston: Assistant desperate   in the menstrual cycle (painful, irregular, prolonged heavy menstruation) associated with increased secretion of estrogen and progesterone reduced secretion (luteal insufficiency), including infertility caused by this condition. When premenstrual syndrome, in which the "guilty" estrogens djufaston also has a positive effect.
Dysfunctional uterine bleeding caused, as a rule, an excess of estrogen or a lack of progesterone may also be the reason for the appointment duphaston.

It is known that estrogens promote the proliferation of the endometrium, resulting in developing diseases such as endometrial hyperplasia and endometriosis - diseases themselves unpleasant and, moreover, sometimes transforming into a malignant tumor. Djufaston inhibits the formation of cancer (carcinogenesis).

Finally, djufaston is used as replacement therapy with estrogen after ovary removal (such as endometriosis or cancer) and during natural menopause after fifty years.

In some cases, djufaston contraindicated

Contraindications for use duphaston virtually none. Absolute contraindication is an idiosyncrasy of its components and breastfeeding (djufaston excreted in human milk, so the period of its application should stop breastfeeding), and relative - the presence of pruritus during a previous pregnancy, indicating that the reaction of the liver. Furthermore, since the producers still allow some side effects from the liver, diseases of the body djufaston be used with caution.

Side effects and overdose duphaston

When receiving duphaston may cause breakthrough uterine bleeding that is associated with significant endometrial growths under the influence of estrogen. Increasing the dose of progesterone suppresses this side effect. It is also possible sensitization mammary glands.

When receiving duphaston not eliminated the side effects of the liver, which appear small violation of its functions with the advent of general malaise. Weakness, pain in the right upper quadrant, and sometimes yellow skin, skin rash Rash: Classification - primary and secondary elements   and itching may also indicate liver reactions.

Very rarely can develop hemolytic (destruction of red blood cells with) anemia. Also very rarely develop swelling and allergic reactions, which occur mostly in the form of urticaria.

No cases of overdose were not observed, but if a woman accidentally took a lot of pills duphaston recommended to wash out the stomach.

Djufaston - quality progestogen, which is widely used in clinical practice.

Galina Romanenko

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