The mechanism of action of diclofenac

Pain, inflammation and fever accompany many diseases caused by both infectious agents and other causes. In all cases, pain and swelling of the tissues, which are always accompanied by inflammation, non-steroidal anti-inflammatory well removed drugs that are sometimes combined with the reception of antibacterial and antiviral agents.

What is a nonsteroidal antiinflammatory drugs

Today, there is a large group of drugs that can remove the signs of inflammation (pain, swelling, fever), whatever they were called. Often these drugs compared with steroid hormones, which are also rapidly reduce inflammation, so they are collectively known nonsteroidal anti-inflammatory drugs (NSAIDs). The very first NSAIDs aspirin was produced in the 19th century, after which he was released on a number of products, significantly exceeding his degree of influence on the inflammatory process, one of these drugs is diclofenac. However, NSAIDs have one major drawback: they irritate the mucous membrane of the gastrointestinal tract.

Diclofenac belongs to the group of nonsteroidal anti-inflammatory drugs, and thus has anti-inflammatory, analgesic and antipyretic properties, as well as the ability to irritate the mucous membrane of the gastrointestinal tract. In order to reduce the irritating effect on the mucosa of the diclofenac tablets include excipients that promote mitigate such effects.

Any inflammatory process necessarily increases the formation of biologically active substances - prostaglandins, which cause inflammatory response. Diclofenac reduces the formation of prostaglandins, thereby reducing the core symptoms of inflammation - pain, swelling and fever. Diclofenac is commonly used in infectious and allergic diseases, such as rheumatoid arthritis, significantly reducing swelling and pain in the joints.

Assign diclofenac for the treatment of pain and inflammation in surgical wounds, which significantly reduces the postoperative period and prevents the proliferation of connective tissue at the site of inflammation (adhesions).

Diclofenac coated tablets which dissolves in the intestine, too irritating the gastric mucosa. After dissolving tablet main substance is rapidly absorbed into the blood, where it is the maximum concentration occurs in two hours. Displayed diclofenac kidney previously decomposing in the liver. Part of diclofenac is excreted in the bile through the gastrointestinal tract. If necessary, if the patient has a contraindication to receiving diclofenac inside, injections of diclofenac solution.

Indications for use of diclofenac

Diclofenac take when various kinds of inflammation and pain:

• for pain and inflammation in the joints and spine (for example, ankylosing spondylitis);
• at pains accompanying metabolic disorders of the joints (for example, arthritis, gout);
• for pain and swelling of the soft tissue surrounding the joint, accompanying rheumatic diseases;
• for pain and inflammation in surgical wounds, including in gynecology;
• for pain and swelling after injuries;
• when expressed pain and inflammation in the background diseases of the nasopharynx and the middle ear.

To receive diclofenac is contraindicated

Diclofenac is contraindicated in:

• if you are hypersensitive to the components of the drug, or are allergic to it;
• with a propensity to bleed (from receiving diclofenac it is amplified);
• children;
• pregnant and lactating women;
• patients with gastric ulcer and 12 duodenal ulcer;
• patients with impaired liver and kidney function.

Side effects that may occur while taking diclofenac

Diclofenac may cause the following side effects:

• from the gastrointestinal tract: abdominal pain, nausea, vomiting, diarrhea, poor appetite, flatulence (bloating), sometimes - gastrointestinal bleeding;
• Central nervous system: headache Headache , Dizziness, weakness, bad mood, blurred vision, hearing, memory, sleep, convulsions;
• the liver and kidneys;
• increased bleeding, because it reduces the number of blood platelets;
• decreased immunity (decreased number of white blood cells - key immune cells);
• at the site of diclofenac appears occasionally soreness and swelling.

Diclofenac - a great tool for pain and inflammation, but it is better to use prescribed by a doctor with all the indications and contraindications.

Galina Romanenko

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