Duphaston is not a universal remedy for infertility, as infertility can have different causes. It is used, for example, in the case where the corpus luteum of the ovary produces enough progesterone, which is the cause of infertility. In this case djufaston administered during the second half of the menstrual cycle for a long time.

The lack of the luteal phase - what is it

Luteal phase insufficiency (LPI), the second half of the menstrual cycle suggests that the ovaries produce inadequate amounts of progesterone. The causes of this condition may be different. Since women's reproductive function provided by the system: the cerebral cortex - the hypothalamus - pituitary - ovary, "failure" may be at any point in the chain. For example, hormonal failure can cause stress (impact on the cerebral cortex) that will reduce the function of the lower links in the chain.

Often the cause of LPI is a depressing effect of other hormones, such as male sex hormones androgens (in women they are always present in a small amount) or pituitary hormone prolactin.

Finally, the cause may be a long time LPI occurring inflammatory processes in the female genital organs, which affects the function of the ovaries.

Lack of adequate amounts of progesterone leads to the fact that the uterine lining (endometrium) is unprepared to introduce into it a fertilized egg. LPI is a sign of infertility. Menstrual irregularities in this case may not occur or are manifested in the form of small spotting a few days before menstruation.

Diagnosis LPI placed by shortening the second phase of the menstrual cycle The phases of the menstrual cycle failures unacceptable   According to the basal body temperature (measured temperature in the rectum in the morning during the second half of the cycle, it should be higher than the first), at low levels of progesterone on the twenty-first - twenty third day of the menstrual cycle and the defective corpus luteum by ultrasound (US) . Also carried out a biopsy (taking a piece of tissue for analysis) of the endometrium during the second phase of the cycle - at LPI noted its lack of secretory transformation.

Djufaston at insufficiency of the luteal phase

Duphaston is a synthetic analogue of progesterone (progestin). All drugs of this series reduces the contractile activity of the muscles of the uterus, inhibit proliferation (proliferation) of the endometrium and translate it into the secretory phase (this phase is necessary for the implementation of the uterine wall of the embryo), reduce the amount of prostaglandins in muscle cells of the uterus (prostaglandins increase the contractility of the muscles), raise platelet count.

Duphaston is used in obstetrics and gynecology for more than forty years. Its chemical formula is slightly different from the formula of natural progesterone, which gives a number of formulation advantages.

Thus, compared with natural progesterone djufaston Djufaston: Assistant desperate   It does not suppress ovulation (release of an egg from the ovary), so in the course of treatment with this drug woman can become pregnant How to Get Pregnant: Recommendations to help . Furthermore, djufaston produces fewer side effects, e.g., it gives substantially no thromboembolic complications of the liver and drowsiness, which are characteristic for other progestogens. Also, this drug is not a derivative of male hormones androgen (progesterone, which is produced in the human body), and therefore does not cause side effects associated with the action of androgens on the body of women and female fetus, and does not cause weight gain.

This drug acts selectively on the endometrium, suppressing the proliferation phase and converting it into a phase of secretion, which leads to the normalization of the menstrual cycle. The endometrium is thus fully prepared for the introduction of a fertilized egg. Unlike progesterone djufaston has greater selectivity for the progesterone receptors, so effective at lower doses.

& gt; IDLF djufaston When administered during the second half of the menstrual cycle (the sixteenth to the twenty-fifth day of the cycle at twenty-eight days) for a long time (up to six months). As a result of this treatment in women menstrual cycle is restored and the endometrium during the second half, which was repeatedly confirmed by ultrasound.

Application duphaston in clinical practice for the treatment of LPI for a long time suggests that this drug is highly effective for the treatment and prevention of menstrual disorders and infertility, resulting in deficiency of the luteal phase.

Galina Romanenko

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