The instructions to djufaston indicates that the drug has no effect on carbohydrate and fat metabolism, so does not cause weight gain. However, some women still djufaston causes weight gain and sometimes considerable. Obviously, this is due to the individual characteristics of the metabolic processes in the female body.

Unlike duphaston of natural hormones

Steroid hormones include female sex hormones, estrogens and progestogens (mainly progesterone), as well as the male sex hormones, androgens (in small quantities and they are present in women). All steroid hormones are similar in structure: they molecule consists of four rings.

Synthetic progestogens have an effect similar to progesterone called progestogen or progestin. They are divided into derivatives of progesterone and androgen derivatives. Their structure is almost the same as that of the progesterone, but has slight differences, characteristic of a particular drug.

Active ingredient in djufaston is digidrosteron, which is a derivative of progesterone, but has small differences in the structure and has no androgenic and estrogenic properties, ie the ability to actively influence the metabolism. But he is able to maintain a positive effect on fat metabolism of estrogens. At the same time it does not cause negative effects on carbohydrate metabolism, and liver function.

Duphaston prescribed in excess in the body of estrogen and progesterone deficiency. He is able to selectively act on the inner lining of the uterus (endometrium), inhibiting its proliferation (proliferation) and causing secretion (mucus and nutrients that support pregnancy). This action of the drug restores menstrual cycle The menstrual cycle - that occurs in different phases? , Abnormal change in the balance of hormones first and second phases of his. Thus djufaston not inhibit ovulation and causes changes in most women metabolism and weight gain.

What causes weight gain

Since djufaston still is a steroid hormone, in some cases it may interact not only progesterone receptors, but also estrogen receptors, androgen, glucocorticoid and so on, resulting in form of side effects manifest properties of these hormones, including weight gain.

This occurs when a woman has some features in individual metabolism. The mechanism of interaction duphaston to receptors of other hormones is not fully understood, as most of this interaction is simply not happening. Individual metabolic changes often occur at the level of liver cells and are associated with the presence or absence of certain enzymes that are required for biochemical reactions.

In most cases djufaston even after prolonged use does not cause weight gain. Sometimes (for example, in the treatment of endometriosis) was appointed for a term of up to six months or more without any impact on metabolism.

This djufaston different from other progestogens. For example, utrozhestan (it contains natural micronized progesterone) is often competes with the application djufaston stimulates formation proteinlipazy enzyme, which leads to an increase in fat stores. Furthermore, utrozhestan actively affects carbohydrate metabolism, enhancing glucose utilization, and contributing to the accumulation of glycogen in the liver and glucose Lishnya as is known, can be transformed into fat.

Thus, djufaston combines with receptors in various organs and tissues, has both positive sometimes (rarely) and a negative impact on a woman's body. At the same time, in most cases it does not have a systemic effect on the body, limited to selective inhibition of proliferation of endometrial proliferation and transfer phase in the phase of secretion.

Adverse reactions in the application duphaston as the impact on the metabolism and increase weight, extremely rare and depend on the individual woman. Duphaston successful application depends on the careful consideration of the indications and contraindications to its use, and predicting possible complications and side effects, including depending on the individual characteristics of metabolic women.

Clinical practice proves that djufaston Djufaston: Assistant desperate   It is a safe drug, which almost no side effects, including the part of metabolism that lead to an increase in weight.

Galina Romanenko

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