As progestogens (female sex hormone progesterone and its analogs) act on the uterine fibroids? This question is currently not fully understood. But today, it is believed that high doses of progestin contained in such formulations as djufaston utrozhestan and contribute to the growth of fibroids, whereas low doses of progestogens contained, for example, hormonal intrauterine device IUD: a reliable and efficient means   Mirena and operating basically only locally inhibit its development.

What are uterine fibroids and its species

Myoma - a benign tumor that develops in the muscle cells of the uterus, forming knots from microscopic to weighing several kilograms. Fibroids in which a lot of connective tissue, called a fibroid. Small fibroids nodules can appear in many women, showing no inclination to growth. But sometimes fibroids grow in size very quickly, compressing the surrounding tissue and organs. It is possible, and fibroid degeneration into a malignant tumor, but today found that this happens very rarely. The main danger with uterine fibroids are persistent uterine bleeding that lead to iron deficiency anemia and complete depletion of women.

Fibroids may have a different location: directly under the inner serous membrane, bulging into the uterine cavity (submucosal), under the outer serous membrane, bulging into the environment (subserous) and in the depth of muscular layer (interstitial).

How is uterine fibroids

Treatment of uterine fibroids depends on its size, location and growth rate. Small, slow-growing nodules fibroids usually treated conservatively, and large sites should definitely be removed surgically. So do a fast-growing units.

Today alternative to surgical treatment for small, rapidly growing fibroids is uterine artery embolization (UAE) - a procedure in which the uterus is injected into the arteries special material covering the lumen of the blood vessel. Since the uterus enters the blood still on the ovarian artery, the body does not suffer, but for the strong growth of uterine tissue nutrients are missing. Therefore sclerosing fibroids (muscle tissue is replaced with connective less volume) and becomes much smaller, no further increase in volume.

There is also a method of destruction of the site of fibroids using focused ultrasound (FUS ablation).

Conservative treatment of uterine fibroids

Until recently this purpose often administered progestins - female sex hormone progesterone and its analogs, for example, and utrozhestan djufaston Djufaston: Assistant desperate . Today, it is believed that progestins contrary, slightly stimulate uterine growth. Maybe slightly stimulate the growth of uterine fibroids and pregnancy, especially in the first half, when progesterone is secreted by many. Therefore djufaston is assigned when hysteromyoma is combined with hyperplasia (swelling) of the uterine mucosa (endometrium), which occurs quite frequently.

Nevertheless, in some cases have a positive effect of progestins and directly with uterine fibroids, inhibiting its growth. For example, most gynecologists agree that the hormonal intrauterine device Mirena, which comprises progestogens, inhibits the growth of fibroids. This is due to the fact that Mirena has mainly local gestagenic action, falling directly into the uterus, causing its efficiency is ensured by very low daily doses of progestogens. Such doses have strong antiproliferative effect (i.e. inhibit overgrowth of tissue), both on the endometrium and the myometrium (muscular layer of the uterus).

To suppress the growth of fibroids today sometimes used drugs that inhibit the action of progesterone, such as mifepristone Mifepristone and misoprostol for abortion: two components of a single method But experience in the use of this drug for the treatment of uterine fibroids is still small.

It is much more effective as a drug for conservative therapy agonists (analogues) of gonadotropin-releasing hormone GnRH (buserelin, Zoladex, and others). They are appointed for a period up to six months, resulting in an artificial menopause comes from the suppression of ovarian function. Prolonged use of this group of drugs is not desirable, as the absence of estrogen leads to the rapid development of osteoporosis, - brittle bones due to the loss of calcium.

Conservative treatment of uterine fibroids - a difficult task, the treatment is chosen individually and depends on many factors. Including sometimes in the combined treatment can be started or djufaston, but only if its destination for actually there are indications in the form of enhanced proliferation of the mucosa of the uterine cavity.

Galina Romanenko

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