Djufaston utrozhestan and include the group of progestogens or progestins, i.e. drugs which have activity of progesterone. Chemical formula utrogestan similar to natural progesterone formula, and the formula has duphaston changes.

What is the progestin or progestin, and how they work

The group of progestogens and progestins include progesterone and its natural and synthetic analogues. Progesterone - a hormone that begins to produce in the second half of the menstrual cycle after ovulation - release of the egg from the ruptured follicle (the bubble in which it matures). Ruptured follicle begins to produce progesterone, and is called the corpus luteum of the menstrual cycle. If pregnancy occurs, the corpus luteum grows and begins to produce a lot more progesterone, transformed into the corpus luteum of pregnancy.

Ovulation occurs under gonadrtropnyh pituitary hormones (TG) - follicle-stimulating hormone (FSH) and luteinizing hormone (LH). FSH promotes the maturation of the egg in the first half of the cycle, and when it matures, this information enters the cortex of the brain and hormonal changes. Ovulation always occurs with a sharp jump in the body content of LH.

In the ovarian hormones (estrogen and progesterone) and the State Tretyakov Gallery there pituitary feedback: the smaller the ovarian hormones, the more GTG stands for stimulation of their synthesis. But if a lot of the ovarian hormones, it inhibits the release of TSH.

So if progesterone or any other progestogen allocated in excess, they inhibit the release of LH and hence ovulation.

In addition, under the influence of progestogens phase of proliferation (increase in the volume of tissue) of the endometrium (the inner lining of the uterus), which is characteristic for the first half of the menstrual cycle, enters the secretory phase - the tissue starts to produce a secret that prepares the endometrium for the introduction of a fertilized egg. This ability progestogens commonly used for the treatment of diseases associated with excessive proliferation of the endometrium against the raised content of estrogen and progesterone deficiency. Such diseases include hyperplasia (excessive proliferation) of the endometrium and endometriosis. Assign it and insufficiency of the luteal phase, when the corpus luteum produces little progesterone.

In the first half of pregnancy progestins are appointed under the threat of miscarriage - they suppress the reduction of uterine muscles.

Features duphaston

Duphaston is a synthetic progestogen, its chemical formula does not fully conform to the formula of progesterone, but manufacturers (pharmaceutical company Abbott, USA) is considered a plus drug. In addition, in the attached instructions to the drug indicated that it does not inhibit ovulation, it can be used without calculating the day of ovulation, since the 14th and 25th day of the menstrual cycle in the luteal phase deficiency. It is believed that such a schedule does not prevent reception of pregnant woman How to Get Pregnant: Recommendations to help .

Another feature duphaston is that due to the change in the chemical formula, it has very few contraindications and side effects. Thus, the contraindication for receiving it is the only individual intolerance of components and the appearance of pruritus (this may be a sign of liver dysfunction) at a previous pregnancy.

Because of the side effects of the drug observed headaches, breakthrough uterine bleeding, increased sensitivity of the mammary glands, small disturbances of liver function (in this case, oddly enough, liver disease Liver disease: when the natural filter faltering   It is not a contraindication for appointment duphaston) and allergic reactions. Characteristic of other progestogens increase blood clotting and thrombosis weight gain djufaston Djufaston: Assistant desperate   It does not.

Clinical experience shows that the quality is really djufaston progestogen, which rarely has side effects. But many gynecologists in the treatment of infertility is still trying to keep track of the time of ovulation, and only then appoint djufaston.

Features utrogestan

Utrozhestan is a natural micronized progestin and is available in capsules of 200 and 100 mg of the French pharmaceutical company Bezen Helska. Micronized form utrogestan ingestion is rapidly absorbed in the gastrointestinal tract and provide a constant concentration in the blood progestogen without sharp fluctuations. In addition, the capsule can be inserted into the vagina, making it easy during pregnancy, if a woman has signs of early toxicity, accompanied by nausea and vomiting.

Utrozhestan has more contraindications and side effects as well as progesterone, which is administered intramuscularly. It inhibits ovulation contributes to body weight, may cause thrombosis and adversely affect the function of the liver. However, clinical practice has established that utrozhestan and well tolerated by women, and rarely give side effects.

So, what drug to choose djufaston utrozhestan or, better to entrust an obstetrician-gynecologist.

Galina Romanenko

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